December 1, 2022

ONWARD Awarded European Innovation Council Grant to Further Develop Brain-Computer Interface Technology; Company also Wins First Place in 2022 Brain-Computer Interface Awards

European Innovation Council (EIC) grant is the second this sort of award presented to ONWARD and its partners to enrich mind-laptop or computer interface technological innovation for the gain of men and women with spinal twine damage

EINDHOVEN, the Netherlands & LAUSANNE, Switzerland & BOSTON, Mass., November 21, 2022–(Enterprise WIRE)–ONWARD Medical N.V. (Euronext: ONWD), the clinical technological know-how firm building revolutionary therapies to restore motion, independence, and wellbeing in persons with spinal twine harm (SCI), these days announced that the Enterprise has been awarded a second grant from the European Innovation Council (EIC) to assistance the improvement of an progressive Mind-Pc Interface (BCI) technology for restoring mobility and upper limb functionality in persons with spinal cord personal injury.

Underneath the EIC Pathfinder funding system, a grant of EUR 3.7 million has been awarded to ONWARD and its exploration partners, including EPFL and CEA-Clinatec.The task is entitled, “Car-Adaptive Neuromorphic Mind Device Interface (NEMO BMI): Toward Totally Embedded Neuroprosthetics.” Underneath the phrases of the grant, ONWARD will acquire EUR 1. million.

The NEMO-BMI task will guidance usability improvements that help the use of a BCI to guidance higher and lessen limb motion. Vehicle-adaptive algorithms will be developed for mind decoding and mind-guided spinal cord stimulation patterns and will then be embedded in miniaturized hardware. The intention of the method is to even more enrich the BCI engineering to make it reliable, smaller, and straightforward to implant, as perfectly as to make improvements to the BCI’s usability and manufacturability.

The NEMO-BMI venture has started and will enhance the ongoing work of the Reverse Paralysis undertaking, for which ONWARD and its analysis companions received an EIC grant of EUR 3.6 million in June 2022. These proceeds are becoming made use of to fund integration involving ONWARD’s implanted ARC-IM system, which provides qualified, programmed stimulation of the spinal cord, and Clinatec’s WIMAGINE, a entirely implantable product permitted for persistent use in scientific trials in two European international locations, which records and decodes the brain’s cortical signal to forecast a person’s ideal movement intentions. When NEMO-BMI is a independent venture from Reverse Paralysis, its goal is to build on the Reverse Paralysis framework and incorporate any enhancements into the joint ONWARD-Clinatec BCI know-how platform. The technological know-how enhancements designed in the NEMO-BMI undertaking will be evaluated independently and then employed in scientific trials as component of the Reverse Paralysis undertaking.

ONWARD and Study Partners Win To start with Put in the 2022 Mind-Laptop Interface Award

Separately, ONWARD introduced that it was the To start with Position Winner of the 2022 Mind-Pc Interface (BCI) Award. The award was granted to ONWARD and a number of study partners for their submission, “Going for walks in a natural way following spinal twine injuries using a brain-backbone interface.” This application concentrated on the do the job being completed less than the Reverse Paralysis challenge to build a absolutely implantable mind-pc interface to assist individuals walk more the natural way right after spinal cord personal injury with the gain of ONWARD’s ARC Therapy.

The Intercontinental BCI Award is a person of the prime accolades in BCI research and was established to recognize exceptional and modern analysis in the area of Brain-Laptop or computer Interfaces. The award is specified by the BCI Award Foundation. This year, more than 100 jobs were being submitted, and the jury chosen 12 finalists, including groups from Stanford University and the College of California San Francisco.

“The supplemental funding from EIC as nicely as the Very first Place in the 2022 Mind-Computer system Interface Awards supply solid validation of the crucial work ONWARD and our associates are executing to advance the use of BCI to improve mobility,” claimed Dave Marver, CEO of ONWARD. “We are collaborating with the best in the field to develop and at some point commercialize a BCI platform that we hope will optimize the usefulness of our therapies to restore motion for men and women living with paralysis.”

About Spinal Twine Damage

Spinal twine injury (SCI) signifies a key unmet health care have to have for which there is no get rid of. Around 7 million men and women globally have a spinal twine injuries, with in excess of 650,000 in the U.S. and Europe on your own. The high-quality of life of folks with SCI can be weak, with paralysis and decline of feeling, issues with blood stress management and trunk stability, enhanced possible for an infection, incontinence, and decline of sexual functionality. Aid is expected for daily residing routines. And SCI is high priced, with the common life time price tag for paraplegia (paralysis of the legs) of $2.5 million and $5 million for tetraplegia (paralysis of all four limbs). Remedies are urgently wanted to restore motion and improve excellent of existence.

About ONWARD Health care

ONWARD is a clinical know-how company producing ground breaking therapies to restore movement, independence, and overall health in people with spinal twine accidents. ONWARD’s function builds on additional than a decade of standard science and preclinical investigate conducted at the world’s main neuroscience laboratories. ONWARD’s ARC Remedy, which can be shipped by implantable (ARC-IM) or exterior (ARC-EX) programs, is developed to deliver qualified, programmed spinal twine stimulation to restore motion and other functions in men and women with spinal cord personal injury, ultimately strengthening their good quality of daily life.

ONWARD has gained five Breakthrough Machine Designations from the U.S. Fda encompassing equally ARC-IM and ARC-EX. ARC-EX is an exterior, non-invasive system consisting of a wearable stimulator and wireless programmer. Favourable leading-line details were being documented in September 2022 from the company’s first pivotal research, called Up-Raise, analyzing the skill of ARC-EX Therapy to improve upper extremity power and function. The corporation is now making ready marketing approval submissions for the U.S. and Europe. ARC-IM is composed of an implantable pulse generator and direct that is put near the spinal cord. The enterprise completed its to start with-in-human use of the ARC-IM neurostimulator in Could 2022.

ONWARD is headquartered in Eindhoven, the Netherlands. It maintains a Science and Engineering Centre in Lausanne, Switzerland, and has a escalating U.S. existence in Boston, Massachusetts. The business has an educational partnership with.NeuroRestore, a collaboration amongst the Swiss Federal Institute of Engineering (EPFL) and Lausanne University Healthcare facility (CHUV). For added data about the business, remember to pay a visit to ONWD.com.

Disclaimer

Selected statements, beliefs and viewpoints in this press launch are forward-on the lookout, which mirror the Enterprise or, as suitable, the Enterprise directors’ existing anticipations and projections about foreseeable future activities. By their mother nature, ahead-searching statements contain various hazards, uncertainties, and assumptions that could induce real final results or events to vary materially from individuals expressed or implied by the ahead-wanting statements. These threats, uncertainties and assumptions could adversely affect the result and fiscal outcomes of the strategies and gatherings described herein. A multitude of factors including, but not minimal to, alterations in desire, opposition, and technological know-how, can result in actual gatherings, overall performance, or benefits to vary drastically from any predicted enhancement. Forward-looking statements contained in this press release relating to earlier developments or functions ought to not be taken as a representation that such traits or activities will proceed in the potential. As a final result, the Enterprise expressly disclaims any obligation or enterprise to release any update or revisions to any forward-on the lookout statements in this press release as a outcome of any change in expectations or any alter in gatherings, disorders, assumptions, or situation on which these forward-on the lookout statements are based. Neither the Company nor its advisers or representatives nor any of its subsidiary undertakings or any these person’s officers or personnel guarantees that the assumptions underlying these types of forward-looking statements are absolutely free from problems nor does both accept any obligation for the upcoming precision of the ahead-searching statements contained in this press release or the actual event of the forecasted developments. You really should not place undue reliance on ahead-on the lookout statements, which speak only as of the day of this push release.

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